1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate
CAS No.:954409-60-0
Molecular Formula:C₃₃H₃₄N₄O₆
Molecular Weight:582.656
Hs Code.:

Synonyms:1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

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Chemical Property of 1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

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Technology Process of 1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

There total 1 articles about 1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405175-79-3
(R)-4-((benzyloxy)carbonyl)piperazine-2-carboxylic acid

: 954409-60-0
1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

Guidance literature:: 1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazole-4-carboxylic acid; With 1-methyl-1H-imidazole; methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 0.333333h;

1-benzyl 3-methyl (3R)-piperazine-1,3-dicarboxylate; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 954409-60-0
1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

: 954409-61-1
benzyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3-(hydroxymethyl)-piperazine-1-carboxylate

Guidance literature:: With lithium borohydride; In methanol; at 0 ℃;
DOI:10.1016/j.bmcl.2008.07.083

Reference yield:

: 954409-60-0
1-benzyl 3-methyl (3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}piperazine-1,3-dicarboxylate

: 954410-00-5
methyl 3-[(3R)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3-(hydroxymethyl)piperazin-1-yl]-1-naphthoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / methanol / 4 h / 0 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 2068.65 Torr

4: caesium carbonate; DavePhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 15 h / 85 °C

With dmap; lithium borohydride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;