4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside

Base Information

• Chemical Name: 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside
• CAS No.: 1410807-78-1
• Molecular Formula: C₂₈H₃₆N₂O₁₀
• Molecular Weight: 560.601
• Mol file: 1410807-78-1.mol

Synonyms:4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside

Chemical Property of 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside

There total 4 articles about 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1,2-dihydro-4-(3-methylphenylmethyl)-5-isopropyl-3H-pyrazol-3-one (1410807-38-3) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside (1410807-78-1)

Guidance literature:

With benzyltri(n-butyl)ammonium chloride; sodium hydroxide; In dichloromethane; water; at 20 ℃;

DOI:10.1016/j.bmc.2012.09.037

Reference yield:

Methanesulfonic acid 3-methyl-benzyl ester (96258-53-6) → 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside (1410807-78-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / Cooling with ice

1.2: 11 h / Reflux

2.1: hydrazine hydrate / toluene / 7 h / Reflux

3.1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / water; dichloromethane / 20 °C

With benzyltri(n-butyl)ammonium chloride; sodium hydride; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; mineral oil;

DOI:10.1016/j.bmc.2012.09.037

Reference yield:

C15H20O3 (1410806-97-1) → 4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside (1410807-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / toluene / 7 h / Reflux

2: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / water; dichloromethane / 20 °C

With benzyltri(n-butyl)ammonium chloride; hydrazine hydrate; sodium hydroxide; In dichloromethane; water; toluene;

DOI:10.1016/j.bmc.2012.09.037

upstream raw materials:

Methanesulfonic acid 3-methyl-benzyl ester

C₁₅H₂₀O₃

1,2-dihydro-4-(3-methylphenylmethyl)-5-isopropyl-3H-pyrazol-3-one

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

Downstream raw materials:

4-(3-methylphenylmethyl)-5-isopropyl-1H-pyrazol-3-yl β-d-glucopyranoside