methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

Base Information

Chemical Name:methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate
CAS No.:1289563-36-5
Molecular Formula:C₂₉H₃₇NO₅Si
Molecular Weight:507.702
Hs Code.:

Synonyms:methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

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Chemical Property of methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

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Technology Process of methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

There total 10 articles about methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 17640-15-2
methyl cyanoformate

: 1289563-32-1
2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole

: 1289563-36-5
methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

Guidance literature:: 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

methyl cyanoformate; In tetrahydrofuran; for 0.0833333h;
DOI:10.1021/jm101597x

Reference yield:

: 1289563-30-9
(6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(oxazol-2-yl)methanol

: 1289563-36-5
methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 0.08 h

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289563-28-5
6-(benzyloxy)-1,2,3,4-tetrahydronaphthalene-2-carboxaldehyde

: 1289563-36-5
methyl 2-((6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

1.2: 0.67 h / -78 °C

1.3: 2 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

3.2: 0.08 h

With 1H-imidazole; n-butyllithium; borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x