tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate
CAS No.:1264534-22-6
Molecular Formula:C₃₃H₄₀N₆O₄S₂
Molecular Weight:648.85
Hs Code.:

Synonyms:tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1264534-18-0
{5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]-thiophen-2-yl}methanol

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1264534-22-6
tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

Guidance literature:: {5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]-thiophen-2-yl}methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

1-t-Butoxycarbonylpiperazine; at 0 - 20 ℃; for 18h;
DOI:10.1021/jm1008902

Reference yield:

: 1264534-16-8
5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophene-2-carbaldehyde

: 1264534-22-6
tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm1008902

Reference yield:

: 1264534-31-7
2-chloro-4-(4-tosylpiperazin-1-yl)quinazoline

: 1264534-22-6
tert-butyl 4-({5-[4-(4-tosylpiperazin-1-yl)quinazolin-2-yl]thiophen-2-yl}methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / Reflux; Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1.1: Suzuki coupling;
DOI:10.1021/jm1008902