Technology Process of ethyl 3-oxo-3-((1S,2R)-2-phenylcyclopropyl)propanoate
There total 7 articles about ethyl 3-oxo-3-((1S,2R)-2-phenylcyclopropyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1S,2R)-2-phenylcyclopropanecarboxylic acid;
With
Carbonyldiimidazole;
In
acetonitrile;
at 20 ℃;
for 0.75h;
ethyl potassium malonate;
With
triethylamine; magnesium chloride;
In
acetonitrile;
at 20 - 80 ℃;
for 2.66667h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium chlorite; aminosulfonic acid / methanol; water / 1 h / 0 °C
2.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 20 °C
2.2: 2 h / 20 - 80 °C
With
sodium chlorite; aminosulfonic acid; 1,1'-carbonyldiimidazole;
In
methanol; water; acetonitrile;
DOI:10.1021/jm3011405
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2’-disulfanediyldipyridine-1-oxide; tris-(trimethylsilyl)silane; 2,2'-azobis(isobutyronitrile); tributylphosphine / benzene / 7.67 h / 20 - 80 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: tetra-n-propylammonium perruthenate.; 4-methyl-2-morpholinone / dichloromethane / 3 h / 20 °C / Inert atmosphere
3.1: aminosulfonic acid; sodium chlorite / water; methanol / 0.5 h / 0 °C / Cooling with ice
4.1: Carbonyldiimidazole / acetonitrile / 0.75 h / 20 °C
4.2: 2.67 h / 20 - 80 °C
With
4-methyl-2-morpholinone; sodium chlorite; Carbonyldiimidazole; tetra-n-propylammonium perruthenate.; 2,2'-azobis(isobutyronitrile); tributylphosphine; tris-(trimethylsilyl)silane; aminosulfonic acid; 2,2’-disulfanediyldipyridine-1-oxide;
In
methanol; dichloromethane; water; acetonitrile; benzene;
