(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

Base Information

Chemical Name:(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)
CAS No.:1256735-87-1
Molecular Formula:C₂₄H₃₀N₄O₄S₂
Molecular Weight:502.659
Hs Code.:

Synonyms:(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

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Technology Process of (2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

There total 5 articles about (2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 56-17-7
cystamine dihydrochioride

: 133712-82-0
3-(p-Tolyl)-2-hydroxyiminopropionic acid

: 1256735-87-1
(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

Guidance literature:: 3-(p-Tolyl)-2-hydroxyiminopropionic acid; With benzotriazol-1-ol; In tetrahydrofuran; at 20 ℃; for 0.666667h;

cystamine dihydrochioride; With dmap; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; at 0 - 20 ℃;
DOI:10.3390/molecules15128784

Reference yield:

: C₁₀H₁₁NO₃

: 56-17-7
cystamine dihydrochioride

: 1256735-87-1
(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 24h; Cooling with ice;
DOI:10.1016/j.bmcl.2015.12.094

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1256735-87-1
(2E,2′E)-N,N′-(disulfanediylbis(ethane-2,1-diyl))bis(2-(hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propanamide)

Guidance literature:: Multi-step reaction with 4 steps

1: ethanolamine / water; ethanol / 5 h / 70 °C / Reflux

2: sodium hydroxide / water / 12 h / 100 °C / Inert atmosphere

3: sodium hydroxide; hydroxylamine hydrochloride; hydrogenchloride / water / 12 h / 20 °C / pH 7 / Cooling with ice

4: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dimethyl sulfoxide / 24 h / 20 °C / Cooling with ice

With hydrogenchloride; hydroxylamine hydrochloride; benzotriazol-1-ol; ethanolamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; 1: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2015.12.094