Technology Process of ethyl 5-amino-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate
There total 7 articles about ethyl 5-amino-2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 10h;
under 760 Torr;
DOI:10.1021/jm00070a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / nitric acid, sulfuric acid / 1.) RT, 16 h, 2.) from 50 deg C to 70 deg C, 1.5 h
2: thionyl chloride / dimethylformamide / 2 h / Heating
3: dimethylformamide
4: Et3N / tetrahydrofuran / 3 h / Ambient temperature
5: 82 percent / H2 / 10percent Pd/C / ethyl acetate / 10 h / 760 Torr
With
thionyl chloride; sulfuric acid; hydrogen; nitric acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / dimethylformamide / 2 h / Heating
2: dimethylformamide
3: Et3N / tetrahydrofuran / 3 h / Ambient temperature
4: 82 percent / H2 / 10percent Pd/C / ethyl acetate / 10 h / 760 Torr
With
thionyl chloride; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00070a012