7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran

Base Information

• Chemical Name: 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran
• CAS No.: 160254-52-4
• Molecular Formula: C₁₈H₁₆O₆
• Molecular Weight: 328.321
• Mol file: 160254-52-4.mol

Synonyms:7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran

Chemical Property of 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran

There total 1 articles about 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R*,7R*)-7-(3,4-dimethoxyphenyl)-6-methoxycarbonyl-4-oxo-4,5,6,7-tetrahydrobenzofuran → 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran (160254-52-4)

Guidance literature:

With pyridinium hydrobromide perbromide; triethylamine; Yield given. Multistep reaction; 1.) acetic acid, 50 deg C, 20 min, 2.) 0 deg C, 5 min;

DOI:10.1246/bcsj.67.3131

Reference yield: 92.0%

chloromethyl methyl ether (107-30-2) + 7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran (160254-52-4) → 7-(3,4-dimethoxyphenyl)-6-methoxycarbonyl-4-methoxymethoxybenzofuran (160254-53-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1246/bcsj.67.3131

Reference yield:

7-(3,4-dimethoxyphenyl)-4-hydroxy-6-methoxycarbonylbenzofuran (160254-52-4) → (2S*,3R*)-2,3-dihydroxy-7-(3,4-dimethoxyphenyl)-6-methoxycarbonyl-4-methoxymethoxy-2,3-dihydrobenzofuran

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / ethyldiisopropylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 88 percent / osmium tetraoxide, N-methylmorpholine N-oxide, water / dioxane; propan-2-ol / 48 h / 50 °C

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; isopropyl alcohol;

DOI:10.1246/bcsj.67.3131

Downstream raw materials:

7-(3,4-dimethoxyphenyl)-6-methoxycarbonyl-4-methoxymethoxybenzofuran