(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Base Information

Chemical Name:(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol
CAS No.:1374851-74-7
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Suppliers and Price of (1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

There total 6 articles about (1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1374851-72-5
(1R,2R,3S,5R)-3-(4-methoxybenzyloxy)-5-vinylcyclopentane-1,2-diol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1374851-74-7
(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

: 1374851-73-6
(1R,2R,3S,5R)-2-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-vinylcyclopentanol

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.tet.2012.03.023

Reference yield:

: 1374851-71-4
(3aR,6R,6aR)-6-vinyldihydro-3aH-spiro[cyclopenta[d][1,3]dioxole-2,1'-cyclopentan]-4(6aH)-one

: 1374851-74-7
(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / 1 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogenchloride / methanol / 25 °C

4.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.03.023

Reference yield:

: C₁₅H₂₄O₃Si

: 1374851-74-7
(1S,2R,3R,5S)-2-(tert-butyldiphenylsilyloxy)-5-(4-methoxybenzyloxy)-3-vinylcyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride; ammonium chloride / tetrahydrofuran; water / 0.5 h / 20 °C

2.1: methanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / 1 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: hydrogenchloride / methanol / 25 °C

5.1: 1H-imidazole; dmap / dichloromethane / 2 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetrabutyl ammonium fluoride; sodium hydride; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.03.023