3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Base Information

Chemical Name:3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide
CAS No.:1310806-00-8
Molecular Formula:C₂₈H₃₁N₃O₅
Molecular Weight:489.571
Hs Code.:

Synonyms:3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Suppliers and Price of 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

There total 5 articles about 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310806-01-9
6-[(3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxybenzoyl)amino]nicotinic acid

: 1310806-00-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Guidance literature:: 6-[(3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxybenzoyl)amino]nicotinic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at -5 ℃; for 0.5h;

Reference yield:

: 1119778-87-8
methyl 3-(4-aminophenoxy)-5-isopropoxybenzoate

: 1310806-00-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 20 °C

2.1: pyridine / dichloromethane / 1 h / 20 °C

3.1: sodium hydroxide; water / methanol / 20 °C

4.1: trichlorophosphate / pyridine / 0.5 h / -5 °C

5.1: sodium hydroxide; water / 1,4-dioxane

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

6.2: 0.5 h / -5 °C

With pyridine; water; sodium tris(acetoxy)borohydride; 1,1'-carbonyldiimidazole; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1310805-94-7
methyl 6-[(3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxybenzoyl)amino]nicotinate

: 1310806-00-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-N-[5-(hydroxymethyl)pyridin-2-yl]-5-isopropoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / 1,4-dioxane

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

2.2: 0.5 h / -5 °C

With water; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane;