(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

Base Information

Chemical Name:(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline
CAS No.:1309462-16-5
Molecular Formula:C₂₂H₂₁NS
Molecular Weight:331.481
Hs Code.:

Synonyms:(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

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Chemical Property of (5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

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Technology Process of (5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

There total 4 articles about (5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309462-05-2
(1S,2S)-2-(benzyl(thiophen-2-ylmethyl)amino)-1,2,3,4-tetrahydronaphthalen-1-ol

: 1309462-16-5
(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

: 1309462-15-4
(6aS,12bS)-6-(thiophen-2-ylmethyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 60 - 65 ℃; for 24h; chemoselective reaction;
DOI:10.1021/ol2008236

Reference yield:

: 1309462-51-8
(1S,2S)-2-(benzyl(thiophen-2-ylmethyl)amino)-1,2-dihydronaphthalen-1-ol

: 1309462-16-5
(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

: 1309462-15-4
(6aS,12bS)-6-(thiophen-2-ylmethyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux

2: aluminum (III) chloride / dichloromethane / 24 h / 60 - 65 °C

With aluminum (III) chloride; sodium acetate; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; dichloromethane; water; 2: Friedel Crafts alkylation;
DOI:10.1021/ol2008236

Reference yield:

: 73325-61-8
N-benzyl-1-(thiophen-2-yl)methanamine

: 1309462-16-5
(5aS,11bS)-5-benzyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline

: 1309462-15-4
(6aS,12bS)-6-(thiophen-2-ylmethyl)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; C₃₂H₄₂FeP₂⁽¹⁺⁾; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux

3: aluminum (III) chloride / dichloromethane / 24 h / 60 - 65 °C

With aluminum (III) chloride; bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; C₃₂H₄₂FeP₂⁽¹⁺⁾; sodium acetate; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; dichloromethane; water; 3: Friedel Crafts alkylation;
DOI:10.1021/ol2008236