(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Base Information

Chemical Name:(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane
CAS No.:221677-51-6
Molecular Formula:C₄₂H₅₈O₅Si
Molecular Weight:671.005
Hs Code.:

Synonyms:(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Suppliers and Price of (1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

There total 8 articles about (1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 201853-25-0
(1S,2R)-2-((S)-2,2-dimethyl[1,3]dioxolan-4-yl)cyclopropane-1-carbaldehyde

: (S)-9-(tert-butyldiphenylsilyloxy)-8-(p-methoxybenzyloxy)-1-nonanyltriphenylphosphonium bromide

: 221677-51-6
(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Guidance literature:: With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)02494-0

Reference yield:

: 103708-37-8
(2S,4S)-4-hydroxymethyl-2-(p-methoxymethyl)-1,3-dioxane

: 221677-51-6
(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / imidazole / dimethylformamide

2: 82 percent / DIBAL-H / toluene

3: 97 percent / pyridine / CH₂Cl₂

4: CuI / tetrahydrofuran

5: 1.) PPTS; 2.) CBr₄, Ph₃P / 1.) EtOH; 2.) CH₂Cl₂

6: acetonitrile / Heating

7: 82 percent / n-BuLi / tetrahydrofuran

With pyridine; 1H-imidazole; copper(l) iodide; n-butyllithium; carbon tetrabromide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(98)02494-0

Reference yield:

: 153861-49-5
(1R,2S,4'S)-1-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-2-(hydroxymethyl)cyclopropane

: 221677-51-6
(1R,2R,4'S,9''S)-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-2-<10''-(tert-butyldiphenylsilyloxy)-9''-(p-methoxybenzyloxy)decen-1''-yl>cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: Swern reagent

2: 82 percent / n-BuLi / tetrahydrofuran

With n-butyllithium; swern reagent; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)02494-0