acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester

Base Information

• Chemical Name: acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester
• CAS No.: 612820-83-4
• Molecular Formula: C₂₃H₁₅FN₂O₂
• Molecular Weight: 370.383

Synonyms:acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester

Chemical Property of acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester

Chemical Property:

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Technology Process of acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester

There total 1 articles about acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

acetic acid 3-chloro-9-cyano-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester (612822-24-9) + 4-fluoroboronic acid (1765-93-1) → acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester (612820-83-4)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; for 24h;

Reference yield:

acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester (612820-83-4) → 3-(4-fluorophenyl)-5-hydroxy-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-9-carbonitrile

Guidance literature:

With methanol; lithium hydroxide; water; for 1h;

Reference yield:

acetic acid 9-cyano-3-(4-fluorophenyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester (612820-83-4) → 3-(4-fluorophenyl)-10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-9-carbonitrile

Guidance literature:

With acetic acid; zinc; for 6h; Heating / reflux;

upstream raw materials:

acetic acid 3-chloro-9-cyano-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-yl ester

4-fluoroboronic acid

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