(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Base Information

Chemical Name:(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)
CAS No.:1394847-34-7
Molecular Formula:C₂₆H₄₆N₄
Molecular Weight:414.678
Hs Code.:

Synonyms:(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Chemical Property:

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Technology Process of (R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

There total 6 articles about (R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

: 1394847-34-7
(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃;
DOI:10.1021/jm300862u

Reference yield:

: 5119-88-0,205526-61-0
(+)-(2R)-2-methylpiperidine hydrochloride

: 1394847-34-7
(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water

2: potassium carbonate / acetonitrile / 8 h / Reflux

3: hydrazine hydrate / ethanol / 1 h / Reflux

4: sodium sulfate / methanol / 24 h / Reflux; Inert atmosphere

5: sodium tetrahydroborate / methanol / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; hydrazine hydrate; sodium sulfate; sodium hydroxide; In methanol; ethanol; water; acetonitrile;
DOI:10.1021/jm300862u

Reference yield:

: 1722-95-8
(2R)-methylpiperidine

: 1394847-34-7
(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 8 h / Reflux

2: hydrazine hydrate / ethanol / 1 h / Reflux

3: sodium sulfate / methanol / 24 h / Reflux; Inert atmosphere

4: sodium tetrahydroborate / methanol / 0 - 20 °C

With sodium tetrahydroborate; potassium carbonate; hydrazine hydrate; sodium sulfate; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm300862u