(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Base Information

Chemical Name:(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline
CAS No.:608533-98-8
Molecular Formula:C₂₇H₂₉N₂O₂P
Molecular Weight:444.513
Hs Code.:

Synonyms:(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

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Chemical Property of (S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

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Technology Process of (S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

There total 5 articles about (S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 608533-88-6
(S)-2-(Diphenyl-phosphinoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ((S)-1-hydroxymethyl-2-methyl-propyl)-amide

: 608533-98-8
(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1016/S0040-4039(03)01561-2

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 608533-98-8
(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile

2: dmap; p-toluenesulfonyl chloride / dichloromethane

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(03)01561-2

Reference yield:

: 79815-19-3,79799-05-6
methyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate

: 608533-98-8
(S)-2-(Diphenyl-phosphinoyl)-3-((R)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran

2: lithium hydroxide / methanol / 24 h / Heating

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile

4: dmap; p-toluenesulfonyl chloride / dichloromethane

With dmap; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(03)01561-2