(R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol

Base Information

• Chemical Name: (R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol
• CAS No.: 1229617-16-6
• Molecular Formula: C₁₅H₂₂OSi
• Molecular Weight: 246.425
• Mol file: 1229617-16-6.mol

Synonyms:(R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol

Chemical Property of (R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol

There total 1 articles about (R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(4-bromo-2-butyn-1-yl)trimethylsilane (121823-55-0) + 2-methylphenyl aldehyde (529-20-4) → (S)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol + (R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol (1229617-16-6)

Guidance literature:

(4-bromo-2-butyn-1-yl)trimethylsilane; With (4S,4'S)-2,2'-(3,6-diphenyl-9H-carbazole-1,8-diyl)bis(4-isopropyl-4,5-dihydrooxazole); chromium dichloride; manganese; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.5h; Inert atmosphere;

2-methylphenyl aldehyde; With chloro-trimethyl-silane; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In water; acetonitrile; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tet.2010.07.065

Reference yield:

(R)-1-o-tolyl-2-((trimethylsilyl)methyl)buta-2,3-dien-1-ol (1229617-16-6) → (S)-2-methylene-1-o-tolylbut-3-en-1-ol (1229617-19-9) + 1-o-tolyl-2-((trimethylsilyl)methylene)but-3-en-1-ol (1246891-32-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1016/j.tet.2010.07.065

upstream raw materials:

(4-bromo-2-butyn-1-yl)trimethylsilane

2-methylphenyl aldehyde

Downstream raw materials:

(S)-2-methylene-1-o-tolylbut-3-en-1-ol

1-o-tolyl-2-((trimethylsilyl)methylene)but-3-en-1-ol