Pyridine-3,5-dicarboxamide

Base Information

• Chemical Name: Pyridine-3,5-dicarboxamide
• CAS No.: 4663-99-4
• Molecular Formula: C7H7N3O2
• Molecular Weight: 165.151
• NSC Number: 523084
• UNII: 3LC6ZJU4SE
• DSSTox Substance ID: DTXSID90326044
• Nikkaji Number: J2.367.426B
• Wikidata: Q82086752
• Mol file: 4663-99-4.mol

Synonyms:pyridine-3,5-dicarboxamide;4663-99-4;3,5-Pyridinedicarboxamide;Dinicotinamide;3LC6ZJU4SE;NSC-523084;NSC523084;UNII-3LC6ZJU4SE;3,5-di(carbamoyl)pyridine;Oprea1_375841;Oprea1_772069;SCHEMBL2841794;DTXSID90326044;MFCD00229426;AKOS003628632;NSC 523084;SB52741;BS-17081;CS-0149968;A872244

Chemical Property of Pyridine-3,5-dicarboxamide

Chemical Property:

• Vapor Pressure: 2.34E-09mmHg at 25°C
• Refractive Index: 1.62
• Boiling Point: 479.5°C at 760 mmHg
• Flash Point: 243.8°C
• Density: 1.375g/cm³
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.053826475
• Heavy Atom Count: 12
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC=C1C(=O)N)C(=O)N

Technology Process of Pyridine-3,5-dicarboxamide

There total 4 articles about Pyridine-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyridine-3,5-dicarbonyl dichloride (15074-61-0) → pyridine-3,5-dicarboxamide (4663-99-4)

Guidance literature:

With ammonia; In 1,4-dioxane; water; for 0.5h;

DOI:10.1021/jo502865f

Reference yield:

dimethyl pyridine-3,5-dicarboxylate (4591-55-3) → pyridine-3,5-dicarboxamide (4663-99-4)

Guidance literature:

With ammonia;

Reference yield:

3,5-Pyridinedicarboxylic acid (499-81-0) → pyridine-3,5-dicarboxamide (4663-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 90 °C / Schlenk technique; Inert atmosphere

2: ammonia / dichloromethane; water / 1 h / -10 - 20 °C / Schlenk technique; Inert atmosphere

With thionyl chloride; ammonia; In dichloromethane; water;

DOI:10.1055/s-0033-1338614

upstream raw materials:

pyridine-3,5-dicarbonyl dichloride

dimethyl pyridine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid

Downstream raw materials:

3,5-dicarbamoyl-1-(2,6-dichlorobenzyl)pyridinium bromide

pyridine-3,5-dicarbonitrile

3,5-diaminopyridine

4-cyano-1-(2,6-dichloro-benzyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diamide