1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene

Base Information

• Chemical Name: 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene
• CAS No.: 1620095-92-2
• Molecular Formula: C₁₆H₁₅F₃O₂
• Molecular Weight: 296.289
• Mol file: 1620095-92-2.mol

Synonyms:1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene

Chemical Property of 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene

There total 3 articles about 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-benzyloxy-3-methoxybenzyl alcohol (33693-48-0) + phenyl 2-bromo-2,2-difluoroacetate → 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene (1620095-92-2)

Guidance literature:

With potassium fluoride; copper(l) iodide; methyl bromodifluoroacetate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile; at 40 - 70 ℃; for 24.5h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1021/acs.joc.8b03072

Reference yield:

1-(benzyloxy)-4-(2,2-difluorovinyl)-2-methoxybenzene (1620096-59-4) → 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene (1620095-92-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 68 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo501289v

Reference yield:

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → 1-(benzyloxy)-2-methoxy-4-(2,2,2-trifluoroethyl)benzene (1620095-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 60 °C / Sealed tube; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 68 °C / Inert atmosphere; Sealed tube

With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo501289v

upstream raw materials:

3-methoxy-4-(phenylmethoxy)benzaldehyde

1-(benzyloxy)-4-(2,2-difluorovinyl)-2-methoxybenzene

4-benzyloxy-3-methoxybenzyl alcohol