2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

Base Information

Chemical Name:2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene
CAS No.:1333480-60-6
Molecular Formula:C₂₆H₂₁F₃
Molecular Weight:390.448
Hs Code.:

Synonyms:2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

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Chemical Property of 2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

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Technology Process of 2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

There total 11 articles about 2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333480-45-7
1-(5-methyl-3,3-diphenylhex-4-en-1-yn-1-yl)-4-(trifluoromethyl)benzene

: 1333480-65-1
C₂₆H₂₁F₃

: 1333480-60-6
2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

Guidance literature:: With Zeise's dimer; trans-4-Octene; In cyclohexane; at 70 - 120 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol202104c

Reference yield:

: 1333480-37-7
4-((4-methoxybenzyl)oxy)-3,3-diphenylbut-1-yne

: 1333480-65-1
C₂₆H₂₁F₃

: 1333480-60-6
2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane

4.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C

4.2: 6 h / -78 - 0 °C

5.1: Zeise's dimer; trans-4-Octene / cyclohexane / 24 h / 70 - 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Zeise's dimer; trans-4-Octene; potassium hexamethylsilazane; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; 1.1: Sonogashira coupling / 4.1: Wittig reaction / 4.2: Wittig reaction;
DOI:10.1021/ol202104c

Reference yield:

: 1333480-35-5
3-((4-methoxybenzyl)oxy)-2,2,-diphenylpropanal

: 1333480-65-1
C₂₆H₂₁F₃

: 1333480-60-6
2-(2-methylprop-1-en-1-yl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)-1H-indene

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 0 °C

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 2 h / 70 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 - 20 °C / pH 7 / aq. phosphate buffer

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane

6.1: potassium hexamethylsilazane / toluene / 0.5 h / 0 °C

6.2: 6 h / -78 - 0 °C

7.1: Zeise's dimer; trans-4-Octene / cyclohexane / 24 h / 70 - 120 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Zeise's dimer; trans-4-Octene; potassium hexamethylsilazane; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; 3.1: Sonogashira coupling / 6.1: Wittig reaction / 6.2: Wittig reaction;
DOI:10.1021/ol202104c