2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

Base Information

Chemical Name:2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate
CAS No.:1602487-65-9
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

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Chemical Property of 2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

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Technology Process of 2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

There total 3 articles about 2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 5538-51-2
O-acetylsalicyloyl chloride

: 366014-01-9
(1R,2R)-2-(2-aminoethyl)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptane

: 1602487-65-9
2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2014.03.025

Reference yield:

: 7787-20-4,126-21-6
(1R)-fenchone

: 1602487-65-9
2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -85 °C / Inert atmosphere

1.2: 1 h / -85 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.025

Reference yield:

: 366013-96-9,324538-17-2,439689-16-4
2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)acetonitrile

: 1602487-65-9
2-(2-((1R,2R,4S)-2-hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)ethylcarbamoyl)phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether

2: triethylamine / dichloromethane / 18 h / 0 - 20 °C

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.025