(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

Base Information

Chemical Name:(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone
CAS No.:26343-66-8
Molecular Formula:C₈H₁₄O₂
Molecular Weight:142.198
Hs Code.:

Synonyms:(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

Chemical Property:

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Technology Process of (R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

There total 8 articles about (R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 82150-10-5
(3S,3aS)-3-Methyl-3,3a,4,5,6,7-hexahydro-benzo[c]isoxazole

: 26343-66-8
(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

Guidance literature:: With hydrogen; boric acid; nickel; In methanol; water; at 23 ℃; for 2h;
DOI:10.1021/ja00356a021

Reference yield:

: 2009-83-8
6-chloro-1-hexanol

: 26343-66-8
(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 6 steps

1: 10.31 g / pyridinium chloroformate / CH₂Cl₂ / 14 h / 23 °C

2: t-BuOK / tetrahydrofuran / 1.) 23 deg C, 15 min, 2.) -78 deg C, 2 h, 3.) 23 deg C, 14 h

3: 3.01 g / NaI / acetone / 12 h / Heating

4: 911 mg / NaNO₂ / dimethylformamide / 3.5 h / 23 °C

5: PhNCO, Et₃N / benzene / 36 h / 23 °C

6: 90 percent / boric acid, H₂ / Raney nickel / methanol; H₂O / 2 h / 23 °C

With pyridinium chloroformate; potassium tert-butylate; hydrogen; boric acid; phenyl isocyanate; triethylamine; sodium iodide; sodium nitrite; nickel; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ja00356a021

Reference yield:

: 52387-36-7
6-chlorohexanal

: 26343-66-8
(R)-2-((S)-1-Hydroxy-ethyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / tetrahydrofuran / 1.) 23 deg C, 15 min, 2.) -78 deg C, 2 h, 3.) 23 deg C, 14 h

2: 3.01 g / NaI / acetone / 12 h / Heating

3: 911 mg / NaNO₂ / dimethylformamide / 3.5 h / 23 °C

4: PhNCO, Et₃N / benzene / 36 h / 23 °C

5: 90 percent / boric acid, H₂ / Raney nickel / methanol; H₂O / 2 h / 23 °C

With potassium tert-butylate; hydrogen; boric acid; phenyl isocyanate; triethylamine; sodium iodide; sodium nitrite; nickel; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ja00356a021