(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

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Chemical Name:(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride
CAS No.:1620955-92-1
Molecular Formula:C₃₀H₂₄N₆O₅*ClH
Molecular Weight:585.019
Hs Code.:

Synonyms:(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

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Chemical Property of (R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

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Technology Process of (R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

There total 12 articles about (R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-91-0
C₃₉H₄₀N₆O₇

: 1620955-92-1
(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1620955-29-4
C₂₀H₁₉BrN₄O₃

: 1620955-92-1
(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

1.2: 12 h / 90 °C

2.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 191338-94-0
ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

: 1620955-92-1
(R)-1-(3-(4'-(4-(hydrazinecarbonyl)-1,6-naphthyridin-2-yl)-[1,1'-biphenyl]-4-yl)isoxazole-5-carbonyl)pyrrolidine-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C

3.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

3.2: 12 h / 90 °C

4.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;