(3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Base Information

• Chemical Name: (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester
• CAS No.: 1207976-45-1
• Molecular Formula: C₄₄H₅₉NO₄
• Molecular Weight: 665.957
• Mol file: 1207976-45-1.mol

Synonyms:(3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Chemical Property of (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

There total 2 articles about (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(18β,20β)-3-(methoxyimino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (1207976-40-6) → (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (1207976-45-1)

Guidance literature:

With hydrogenchloride; N-tert-butylaminoborane; In 1,4-dioxane; ethanol; water; at 0 ℃;

DOI:10.1016/j.bmc.2009.10.036

Reference yield: 14.0%

(18β,20β)-3-(methoxyimino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (1207976-40-6) → (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (1207976-45-1) + (3α,18β,20β)-3-methoxyamino-11-oxo-olean-12-en-29-oic acid diphenylmethyl ester (1257867-07-4)

Guidance literature:

With hydrogenchloride; C₄H₁₂BN*H⁽¹⁺⁾; In 1,4-dioxane; ethanol; water; at 0 ℃; for 2.5h;

DOI:10.1016/j.bmc.2010.08.046

Reference yield: 27.9%

2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide (572-09-8,3068-32-4,4026-32-8,6919-96-6,13242-53-0,14227-54-4,14795-18-7,19186-59-5,19285-38-2,21698-13-5,29907-26-4,53369-42-9,60619-58-1,61303-35-3,67337-79-5,69127-37-3,70749-15-4,72002-90-5,75247-30-2,75880-74-9,78418-57-2,102339-89-9,102339-90-2,103530-40-1,114028-03-4,114718-45-5,138514-70-2,138514-71-3) + (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (1207976-45-1) → (3S,18R,20S)-11-oxo-3-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)methoxamino]-olean-12-en-29-oic acid diphenylmethyl ester (1257409-34-9)

Guidance literature:

2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide; (3β,18β,20β)-3-(methoxyamino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester; Silver-Zeolite; In dichloromethane; at 20 ℃; Molecular sieve;

With potassium carbonate; In water; acetone; at 20 ℃; for 3h;

upstream raw materials:

(18β,20β)-3-(methoxyimino)-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Downstream raw materials:

(3S,18R,20S)-11-oxo-3-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)methoxamino]-olean-12-en-29-oic acid diphenylmethyl ester