(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid
CAS No.:1410861-13-0
Molecular Formula:C₁₄H₂₃NO₄
Molecular Weight:271.325
Hs Code.:

Synonyms:(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

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Chemical Property of (S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

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Technology Process of (S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

There total 3 articles about (S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1410861-10-7
(S)-methyl 2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoate

: 1410861-13-0
(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

Guidance literature:: With water; sodium hydroxide; In deuteromethanol; at 60 ℃; for 1h;
DOI:10.1021/ol3029548

Reference yield:

: 1410861-46-9
(2S,3S)-2-[(S)-1-(tert-butoxycarbonylamino)-2-methoxy-2-oxoethyl]-3-deutero-3-((E)-1-deuteroprop-1-enyl)oct-7-enoic acid

: 1410861-13-0
(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Grubbs catalyst first generation / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: P,P-dichlorophenylphosphine oxide; triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / -10 °C / Inert atmosphere; Darkness

2.3: 3 h / -10 °C / Inert atmosphere

3.1: sodium hydroxide; water / deuteromethanol / 1 h / 60 °C

With Grubbs catalyst first generation; P,P-dichlorophenylphosphine oxide; water; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; deuteromethanol;
DOI:10.1021/ol3029548

Reference yield:

: (2S,3S)-3-(tert-butoxycarbonylamino)-2-[(S)-1,2-dideuterocyclohex-2-enyl]-4-methoxy-4-oxobutanoic acid

: 1410861-13-0
(S)-2-(tert-butoxycarbonylamino)-3-[(R)-1,2-dideuterocyclohex-2-enyl]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: P,P-dichlorophenylphosphine oxide; triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / -10 °C / Inert atmosphere; Darkness

1.3: 3 h / -10 °C / Inert atmosphere

2.1: sodium hydroxide; water / deuteromethanol / 1 h / 60 °C

With P,P-dichlorophenylphosphine oxide; water; triethylamine; sodium hydroxide; In tetrahydrofuran; deuteromethanol;
DOI:10.1021/ol3029548