3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

Base Information

Chemical Name:3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester
CAS No.:105189-46-6
Molecular Formula:C₂₆H₂₃Br₂F₃N₂O₆
Molecular Weight:676.282
Hs Code.:

Synonyms:3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

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Chemical Property of 3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

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Technology Process of 3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

There total 7 articles about 3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 105189-46-6
3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N / CH₂Cl₂ / 19 h / Ambient temperature

With pyridine; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00122a009

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 105189-46-6
3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N / CH₂Cl₂ / 19 h / Ambient temperature

With pyridine; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00122a009

Reference yield:

: 105189-38-6
(2-methoxyphenyl)(2-methoxypyrid-5-yl)methanol

: 105189-46-6
3,5-dibromo-3'-<(2-methoxypyrid-5-yl)methyl>-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 50 °C

2: H₂ / 10percent Pd/C / methanol

3: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

4: Cu bronze, Et₃N / CH₂Cl₂ / 19 h / Ambient temperature

With pyridine; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00122a009