[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester
• CAS No.: 403736-50-5
• Molecular Formula: C₃₂H₃₅N₃O₇
• Molecular Weight: 573.646
• Mol file: 403736-50-5.mol

Synonyms:[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester

Chemical Property of [2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester

There total 1 articles about [2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

glycine tert-butyl ester hydrochloride (27532-96-3) + Nα-Cbz-Nβ-Fmoc-Apa (142855-80-9) → [2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester (403736-50-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield: 93.0%

[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester (403736-50-5) → Nα-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester (403736-54-9)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(01)00228-0

Reference yield:

[2-benzyloxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid tert-butyl ester (403736-50-5) → [(S)-2-Benzyloxycarbonylamino-3-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-propionylamino]-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / diethylamine / acetonitrile / 12 h / 20 °C

2: 19 percent / triethylamine; NaI / acetonitrile / 12 h / 90 °C

3: 100 percent / HCl / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; diethylamine; triethylamine; sodium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/S0968-0896(01)00228-0

upstream raw materials:

glycine tert-butyl ester hydrochloride

N^α-Cbz-N^β-Fmoc-Apa

Downstream raw materials:

N_α-carbobenzyloxy-2,3-diamino-L-propionylglycin tert-butyl ester

[2-benzyloxycarbonylamino-3-(3-methoxy-[1,2,4]thiadiazol-5-ylamino)-propionylamino]-acetic acid tert-butyl ester