2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

Base Information

• Chemical Name: 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide
• CAS No.: 1422678-53-2
• Molecular Formula: C₂₁H₁₅BrCl₂F₃N₅O₂S
• Molecular Weight: 609.254

Synonyms:2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

Chemical Property of 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

Chemical Property:

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Technology Process of 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

There total 3 articles about 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ⁴-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

8-bromo-6-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-benzo[d][1,3]oxazin-4-one (934405-58-0) + 2,4,6-trimethylbenzenesulfonate 1-amino-tetrahydro-λ4-thiophenium → 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ4-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide (1422678-53-2)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 - 25 ℃; for 24h;

Reference yield:

8-bromo-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (122588-67-4) → 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ4-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide (1422678-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetonitrile / 20.5 h / 20 - 100 °C

2: potassium tert-butylate / dimethyl sulfoxide / 24 h / 20 - 25 °C

With pyridine; potassium tert-butylate; In dimethyl sulfoxide; acetonitrile;

Reference yield:

2-amino-3-bromo-5-chlorobenzoic acid (41198-02-1) → 2-(3-chloro-2-pyridyl)-N-[2-bromo-4-chloro-6-[(tetrahydro-λ4-thiophenidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide (1422678-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene; 1,4-dioxane / 48 h / 20 - 25 °C

2: pyridine / acetonitrile / 20.5 h / 20 - 100 °C

3: potassium tert-butylate / dimethyl sulfoxide / 24 h / 20 - 25 °C

With pyridine; potassium tert-butylate; In 1,4-dioxane; dimethyl sulfoxide; toluene; acetonitrile;

upstream raw materials:

8-bromo-6-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

2-amino-3-bromo-5-chlorobenzoic acid

8-bromo-6-chloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-benzo[d][1,3]oxazin-4-one

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