1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

Base Information

Chemical Name:1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one
CAS No.:192643-49-5
Molecular Formula:C₃₇H₄₆N₄O
Molecular Weight:562.798
Hs Code.:

Synonyms:1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

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Chemical Property of 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

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Technology Process of 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

There total 8 articles about 1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {2-[5-[2-(7-aza-bicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethyl}-(4-pyridin-4-yl-butyl)-carbamic acid benzyl ester

: 192643-49-5
1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

Guidance literature:: With hydrogen; palladium dihydroxide; In 2-methoxy-ethanol;
DOI:10.1016/S0960-894X(01)00275-X

Reference yield:

: 279-40-3
7-aza-bicyclo[2.2.1]heptane

: 192643-49-5
1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: PyBOP; Et₃N / CH₂Cl₂

2: H₂ / Pd(OH)2 / 2-methoxy-ethanol

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; palladium dihydroxide; In dichloromethane; 2-methoxy-ethanol;
DOI:10.1016/S0960-894X(01)00275-X

Reference yield:

: 5264-15-3
4-(4-pyridinyl)butan-1-ol

: 192643-49-5
1-(7-azabicyclo[2.2.1]hept-7-yl)-2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-4-yl)butylamino]ethyl]-1H-indol-5-yl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / -65 - -60 °C

2: Mg₂SO₄ / CDCl₃ / -10 - -5 °C

3: NaBH₄ / methanol / -5 °C

4: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

5: aq. KOH / methanol / Heating

6: PyBOP; Et₃N / CH₂Cl₂

7: H₂ / Pd(OH)2 / 2-methoxy-ethanol

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; magnesium sulfate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; dichloromethane; 2-methoxy-ethanol;
DOI:10.1016/S0960-894X(01)00275-X