2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid

Base Information

• Chemical Name: 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid
• CAS No.: 1352067-76-5
• Molecular Formula: C₂₈H₂₈Cl₂N₂O₃
• Molecular Weight: 511.448
• Mol file: 1352067-76-5.mol

Synonyms:2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid

Chemical Property of 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid

There total 3 articles about 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-(1-(pyridin-2-yl)propyl)piperidin-2-one → 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid (1352067-76-5)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 0.75h;

DOI:10.1021/ml500142b

Reference yield:

2-(1-bromopropyl)pyridine (333969-32-7) → 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid (1352067-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

1.2: 3.17 h / 0 - 20 °C

2.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C

With ruthenium trichloride; sodium periodate; sodium hydride; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.1021/ml500142b

Reference yield:

2-propylpyridine (622-39-9) → 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid (1352067-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: azobisisobutyronitrile; N-Bromosuccinimide / tetrachloromethane / 12 h / 20 °C / Irradiation

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.13 h / 0 °C / Inert atmosphere

2.2: 3.17 h / 0 - 20 °C

3.1: sodium periodate; ruthenium trichloride / acetonitrile; tetrachloromethane; water / 0.75 h / 20 °C

With ruthenium trichloride; sodium periodate; N-Bromosuccinimide; azobisisobutyronitrile; sodium hydride; In tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.1021/ml500142b

upstream raw materials:

2-(1-bromopropyl)pyridine

2-propylpyridine