(E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide

Base Information

• Chemical Name: (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide
• CAS No.: 115205-47-5
• Molecular Formula: C₂₀H₂₃NOS
• Molecular Weight: 325.475
• Mol file: 115205-47-5.mol

Synonyms:(E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide

Chemical Property of (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide

There total 4 articles about (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxy-1-phenyl-2-phenylsulfanyl-ethanol (89036-90-8) → (Z)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide (115205-47-5,115205-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / MeSO₂Cl, Et₃N / benzene; hexane / 0.25 h / 0 °C

2: tetrahydrofuran / 10 h / 50 °C

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; benzene;

DOI:10.1021/ja00223a060

Reference yield:

2-Methoxy-1-phenyl-2-phenylsulfanyl-ethanol (89036-90-8) → (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide (115205-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / MeSO₂Cl, Et₃N / benzene; hexane / 0.25 h / 0 °C

2: tetrahydrofuran / 10 h / 50 °C

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; benzene;

DOI:10.1021/ja00223a060

Reference yield:

Phenyl(phenylthio)acetaldehyd (35874-96-5) + <(N,N-Diethylcarbamoyl)methylidene>triphenylphosphorane (6080-83-7) → (Z)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide (115205-47-5,115205-48-6) + (E)-4-Phenyl-4-phenylsulfanyl-but-3-enoic acid diethylamide (115205-47-5)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 10h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00223a060

upstream raw materials:

Phenyl(phenylthio)acetaldehyd

<(N,N-Diethylcarbamoyl)methylidene>triphenylphosphorane

2-Methoxy-1-phenyl-2-phenylsulfanyl-ethanol

Downstream raw materials:

N,N-diethyl-4-oxo-4-phenylbutanamide