N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide
• CAS No.: 1397342-92-5
• Molecular Formula: C₂₀H₃₄N₂O₂SSi
• Molecular Weight: 394.654

Synonyms:N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide

Chemical Property of N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide

There total 2 articles about N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(S_S)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyanobromobenzene (6952-59-6) + N-[3-(tert-butyldimethylsilanyloxy)prop-(E)-ylidene]-(SS)-2-methylpropane-2-sulfinamide (1397342-89-0) → N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(SS)-2-methylpropane-2-sulfinamide (1397342-92-5)

Guidance literature:

3-cyanobromobenzene; With isopropylmagnesium chloride; lithium chloride; In tetrahydrofuran; at -15 - -5 ℃; for 0.5h; Inert atmosphere;

N-[3-(tert-butyldimethylsilanyloxy)prop-(E)-ylidene]-(S_S)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; toluene; at -78 ℃; for 16h;

Reference yield:

(3-cyanophenyl)magnesium bromide + (SS)-N-{3-[(tert-butyldimethylsilyl)oxy]propylidene}-2-methylpropane-2-sulfinamide (1256375-11-7) → N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(SS)-2-methylpropane-2-sulfinamide (1397342-92-5)

Guidance literature:

In tetrahydrofuran;

Reference yield:

N-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(3-cyanophenyl)propyl]-(SS)-2-methylpropane-2-sulfinamide (1397342-92-5) → 3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride (1391439-21-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

upstream raw materials:

3-cyanobromobenzene

N-[3-(tert-butyldimethylsilanyloxy)prop-(E)-ylidene]-(S_S)-2-methylpropane-2-sulfinamide

(S_S)-N-{3-[(tert-butyldimethylsilyl)oxy]propylidene}-2-methylpropane-2-sulfinamide

Downstream raw materials:

3-[(S)-3-hydroxy-1-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-2-ylamino)propyl]benzonitrile

3-((S)-1-amino-3-hydroxypropyl)benzonitrile hydrochloride

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