N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Base Information

Chemical Name:N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide
CAS No.:1186240-81-2
Molecular Formula:C₃₃H₄₅ClN₆O₅S
Molecular Weight:673.277
Hs Code.:

N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Synonyms:N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Chemical Property of N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Technology Process of N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

There total 10 articles about N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1186240-93-6
2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid

: N-((4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide dihydrochloride

: 1186240-81-2
N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 0.25h;

N-((4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide dihydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 25 ℃; for 16h;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1186240-81-2
N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / methanol; water / 1 h / 20 °C

2.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 20 - 50 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: hydrogen; acetic acid / palladium(II) hydroxide / methanol / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

6.1: water; sodium hydroxide / methanol / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 2 h / 20 °C

8.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 - 25 °C

9.2: 16 h / 0 - 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1186241-36-0
1-benzyl-4-(4-cyclopropylpiperazin-1-yl)piperidine-4-carbonitrile

: 1186240-81-2
N-((1-(2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetyl)-4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran / 20 - 50 °C

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: hydrogen; acetic acid / palladium(II) hydroxide / methanol / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

5.1: water; sodium hydroxide / methanol / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 - 25 °C

8.2: 16 h / 0 - 25 °C

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;