3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

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Chemical Name:3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile
CAS No.:1357610-36-6
Molecular Formula:C₂₄H₁₆BrCl₃F₃N₃O₂
Molecular Weight:621.668
Hs Code.:

Synonyms:3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

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Chemical Property of 3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

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Technology Process of 3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

There total 8 articles about 3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1357614-82-4
3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidine-3-carbonitrile

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1357610-36-6
3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: C₁₅H₁₉BrN₂O₂

: 1357610-36-6
3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2.2: 1.17 h / 20 - 65 °C

3.1: N-chloro-succinimide / ethyl acetate / 0.25 h / 55 °C

3.2: 20 °C

4.1: hydrogenchloride / methanol / 3 h / 65 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 1357614-76-6
1-benzhydryl-3-(2-bromo-4-(diethoxymethyl)phenyl)azetidine-3-carbonitrile

: 1357610-36-6
3-(2-bromo-4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-1-(cyclopropanecarbonyl)azetidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2-Chloroethyl chloroformate / acetonitrile / 3 h / 0 °C / Reflux

2.1: 0.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3.2: 1.17 h / 20 - 65 °C

4.1: N-chloro-succinimide / ethyl acetate / 0.25 h / 55 °C

4.2: 20 °C

5.1: hydrogenchloride / methanol / 3 h / 65 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate; acetonitrile;