Technology Process of (4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone
There total 6 articles about (4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]pyrrolidin-1-yl}methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-chloro-2-(2H-1,2,3-triazol-2-yl)benzoic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 0.25h;
Inert atmosphere;
3-(S)-pyrrolidin-2-yl-5-(2-trifluoromethoxyphenyl)-[1,2,4]oxadiazole;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/cmdc.201900618
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride / methanol / 70 °C / Inert atmosphere
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
2.3: 48 h / 80 °C / Inert atmosphere
3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 20 °C / Inert atmosphere
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / Inert atmosphere
4.2: 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; hydroxylamine hydrochloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/cmdc.201900618
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate; trans-N,N′-dimethyl-1,2-cyclohexane diamine / N,N-dimethyl-formamide / 0.25 h / 105 °C / Inert atmosphere; Microwave irradiation
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
With
trans-N,N′-dimethyl-1,2-cyclohexane diamine; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900618
