(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

Base Information

Chemical Name:(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate
CAS No.:1417912-31-2
Molecular Formula:C₁₄H₁₅ClFNO₄
Molecular Weight:315.729
Hs Code.:

Synonyms:(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

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Chemical Property of (2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

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Technology Process of (2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

There total 2 articles about (2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2343-89-7
methyl 2-fluoroprop-2-enoate

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1417912-31-2
(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; (S)-TF-Biphamphos; triethylamine; In dichloromethane; at 20 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1002/cjoc.201200765

Reference yield:

: 2343-89-7
methyl 2-fluoroprop-2-enoate

: 76862-09-4
methyl N-(4-chlorobenzylidene)glycinate

: 1417912-31-2
(2R,4S,5R)-dimethyl 5-(4-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate

: C₁₄H₁₅ClFNO₄

Guidance literature:: With tetrakis(acetonitrile)copper(I)tetrafluoroborate; (S)-TF-Biphamphos; triethylamine; In dichloromethane; at 20 ℃; for 0.2h; Overall yield = 83 %; diastereoselective reaction;
DOI:10.1002/cjoc.201200765