prostaglandin D₂

Base Information

• Chemical Name: prostaglandin D₂
• CAS No.: 65026-04-2
• Molecular Formula: C₂₀H₃₂O₅
• Molecular Weight: 352.471

Synonyms:prostaglandin D₂

Chemical Property of prostaglandin D₂

Chemical Property:

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Technology Process of prostaglandin D₂

There total 8 articles about prostaglandin D₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(S)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid (87789-17-1,87789-18-2) → PGD2 (41598-07-6,54396-59-7,59894-05-2,64072-55-5,65026-03-1,65026-04-2,65026-05-3,69779-97-1)

Guidance literature:

With acetic acid; at 20 ℃; for 20h;

DOI:10.1016/S0040-4039(00)88113-7

Reference yield: 70.0%

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(R)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid (87789-17-1,87789-18-2) → (Z)-7-[(1S,2S,5R)-5-Hydroxy-2-((E)-(S)-3-hydroxy-oct-1-enyl)-3-oxo-cyclopentyl]-hept-5-enoic acid (41598-07-6,54396-59-7,59894-05-2,64072-55-5,65026-03-1,65026-04-2,65026-05-3,69779-97-1)

Guidance literature:

With acetic acid; at 20 ℃; for 20h;

DOI:10.1016/S0040-4039(00)88113-7

Reference yield:

prostaglandin H2 (42935-17-1,127969-05-5) → prostaglandin D2 (65026-04-2) + dinoprostone (363-24-6) + levuglandin LGE2 (91712-44-6) + levuglandin E2

Guidance literature:

In dimethyl sulfoxide; at 37 ℃; for 1h;

DOI:10.1194/jlr.M017053

upstream raw materials:

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(S)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(S)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid methyl ester

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(R)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid

(Z)-7-[(6R,7R,8S)-8-Hydroxy-6-((E)-(R)-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-7-yl]-hept-5-enoic acid methyl ester

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