2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone

Base Information

• Chemical Name: 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone
• CAS No.: 1185746-34-2
• Molecular Formula: C₂₉H₂₀N₂OS₂
• Molecular Weight: 476.623
• Mol file: 1185746-34-2.mol

Synonyms:2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone

Chemical Property of 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone

There total 2 articles about 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,2-bis(5-methyl-2-phenyl-4-thiazolyl)ethyne (1185746-26-2) + 2-methoxycarbonylphenylboronic acid (374538-03-1) → 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone (1185746-34-2)

Guidance literature:

With palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In methanol; N,N-dimethyl-formamide; at 80 - 110 ℃; for 78h; Inert atmosphere;

DOI:10.1021/ol901497t

Reference yield:

C29H20N2OS2 (1185746-27-3) → 2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone (1185746-34-2)

Guidance literature:

In acetonitrile; Quantum yield; Irradiation;

DOI:10.1021/ol901497t

Reference yield: 82.0%

2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone (1185746-34-2) + methyllithium (917-54-4) → 1-methyl-2,3-bis(5-methyl-2-phenyl-4-thiazolyl)-1-indenol (1415807-32-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/c2cc35793c

upstream raw materials:

C₂₉H₂₀N₂OS₂

1,2-bis(5-methyl-2-phenyl-4-thiazolyl)ethyne

2-methoxycarbonylphenylboronic acid

Downstream raw materials:

C₂₉H₂₀N₂OS₂

2,3-bis(5-methyl-2-phenyl-4-thiazolyl)indenone ethylene acetal

1-methyl-2,3-bis(5-methyl-2-phenyl-4-thiazolyl)-1-indenol

2,3-bis(5-methyl-2-phenyl-4-thiazolyl)-1-phenyl-1-indenol

Refernces