Technology Process of (S)-4-Benzyl-3-((4S,5R)-5-phenyl-2-thioxo-oxazolidine-4-carbonyl)-oxazolidin-2-one
There total 6 articles about (S)-4-Benzyl-3-((4S,5R)-5-phenyl-2-thioxo-oxazolidine-4-carbonyl)-oxazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 84 percent / potassium carbonate / 2 h / 135 - 140 °C
3: n-butyllithium / hexane; tetrahydrofuran / 15 min, -78 deg C; 15 min, r.t.
4: sodium azide / tetrabutylammonium hydrogen sulfate / H2O; CH2Cl2 / 1 h / Ambient temperature
5: 1.) hydrogen, 70percent perchloric acid; 2.) sodium bicarbonate / 1.) 10percent palladium on carbon / 1.) water, methanol, 1 atm, overnight; 2.) water, chloroform, 10 min, r.t.
6: 1.) stannous triflate, N-ethylpiperidine / 1.) THF, -78 deg C, 1.5 h; 2.) -78 deg C
With
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; n-butyllithium; sodium azide; perchloric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ja00281a049
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / potassium carbonate / 2 h / 135 - 140 °C
2: n-butyllithium / hexane; tetrahydrofuran / 15 min, -78 deg C; 15 min, r.t.
3: sodium azide / tetrabutylammonium hydrogen sulfate / H2O; CH2Cl2 / 1 h / Ambient temperature
4: 1.) hydrogen, 70percent perchloric acid; 2.) sodium bicarbonate / 1.) 10percent palladium on carbon / 1.) water, methanol, 1 atm, overnight; 2.) water, chloroform, 10 min, r.t.
5: 1.) stannous triflate, N-ethylpiperidine / 1.) THF, -78 deg C, 1.5 h; 2.) -78 deg C
With
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; n-butyllithium; sodium azide; perchloric acid; hydrogen; sodium hydrogencarbonate; potassium carbonate;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ja00281a049
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium azide / tetrabutylammonium hydrogen sulfate / H2O; CH2Cl2 / 1 h / Ambient temperature
2: 1.) hydrogen, 70percent perchloric acid; 2.) sodium bicarbonate / 1.) 10percent palladium on carbon / 1.) water, methanol, 1 atm, overnight; 2.) water, chloroform, 10 min, r.t.
3: 1.) stannous triflate, N-ethylpiperidine / 1.) THF, -78 deg C, 1.5 h; 2.) -78 deg C
With
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; sodium azide; perchloric acid; hydrogen; sodium hydrogencarbonate;
palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate;
In
dichloromethane; water;
DOI:10.1021/ja00281a049