Chemical Property of Sutezolid
Chemical Property:
- Vapor Pressure:8.97E-15mmHg at 25°C
- Melting Point:186-187°C
- Boiling Point:609°C at 760 mmHg
- PKA:15.53±0.46(Predicted)
- Flash Point:322.1°C
- PSA：87.18000
- Density:1.321g/cm3
- LogP:2.36110
- Storage Temp.:room temp
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:1.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:4
- Exact Mass:353.12094084
- Heavy Atom Count:24
- Complexity:476
- Purity/Quality:
-
99%, *data from raw suppliers
Sutezolid
*data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCSCC3)F
- Isomeric SMILES:CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCSCC3)F
- Recent ClinicalTrials:PanACEA Sutezolid Dose-finding and Combination Evaluation
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Description
PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.
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Uses
Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).
