(3S)-<amino>-1-chloro-4-phenyl-2-butanone

Base Information

Chemical Name:(3S)-<amino>-1-chloro-4-phenyl-2-butanone
CAS No.:127231-58-7
Molecular Formula:C₁₉H₂₆ClN₃O₅
Molecular Weight:411.886
Hs Code.:

(3S)-<<N-(tert-butoxycarbonyl)asparaginyl>amino>-1-chloro-4-phenyl-2-butanone

Synonyms:(3S)-<amino>-1-chloro-4-phenyl-2-butanone

Suppliers and Price of (3S)-<amino>-1-chloro-4-phenyl-2-butanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-<amino>-1-chloro-4-phenyl-2-butanone

Chemical Property:

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Technology Process of (3S)-<amino>-1-chloro-4-phenyl-2-butanone

There total 3 articles about (3S)-<amino>-1-chloro-4-phenyl-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 127231-58-7
(3S)-<amino>-1-chloro-4-phenyl-2-butanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine (NMM), isobutyl chloroformate / 1.) THF, -25 deg C, 5 min, 2.) THF, ether, -70 deg C to RT

2: 97 percent / 4 N HCl / dioxane / 1 h / Ambient temperature

3: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; isobutyl chloroformate; In 1,4-dioxane;
DOI:10.1021/jm00099a008

Reference yield:

: 60398-41-6
(3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate

: 127231-58-7
(3S)-<amino>-1-chloro-4-phenyl-2-butanone

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 4 N HCl / dioxane / 1 h / Ambient temperature

2: 1.) hydroxybenzotriazole (HOBt), EDCI, 2.) N-methylmorpholine (NMM) / 1.) DMF, 40 min, 2.) DMF, a) 0 deg C, 2 h, b) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; In 1,4-dioxane;
DOI:10.1021/jm00099a008

Reference yield:

: 7536-55-2
N-tert-butyloxycarbonylasparagine

: 34351-19-4
(3S)-3-amino-1-chloro-4-phenyl-2-butanone hydrochloride

: 127231-58-7
(3S)-<amino>-1-chloro-4-phenyl-2-butanone

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Multistep reaction;
DOI:10.1021/jm00167a003