3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

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Chemical Name:3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide
CAS No.:1365647-51-3
Molecular Formula:C₂₃H₂₁N₅O₄
Molecular Weight:431.451
Hs Code.:

Synonyms:3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

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Chemical Property of 3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

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Technology Process of 3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

There total 4 articles about 3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1092395-04-4
3-(1-cyano-1-methylethyl)-N-(3-hydroxyphenyl)benzamide

: 33742-70-0
6-chloro-N-methyl-3-nitropyridin-2-amine

: 1365647-51-3
3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm300126x

Reference yield:

: 872091-85-5
methyl 3-(1-cyano-1-methylethyl)benzoate

: 1365647-51-3
3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 18 h / 20 °C

2: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x

Reference yield:

: 872091-00-4
3-(1-cyano-1-methylethyl)benzoic acid

: 1365647-51-3
3-(1-cyano-1-methylethyl)-N-(3-{[6-(methylamino)-5-nitropyridin-2-yl]oxy}phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 4 - 20 °C

2: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300126x