5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

Base Information

Chemical Name:5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile
CAS No.:421558-49-8
Molecular Formula:C₂₂H₂₁FN₂O₂
Molecular Weight:364.419
Hs Code.:

Synonyms:5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

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Chemical Property of 5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

Chemical Property:

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Technology Process of 5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

There total 5 articles about 5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2E,4E)-5-[3-Fluoro-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-penta-2,4-dienenitrile

: 421558-49-8
5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; under 760 Torr;
DOI:10.1248/cpb.50.100

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 421558-49-8
5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: 81 percent / NaH / dimethylformamide / 3 h / 20 °C

2.1: 100 percent / H₂ / 5 percent Pd/C / tetrahydrofuran / 760 Torr

3.1: aq. NaNO₂; HBr / methanol; acetone / 0.25 h / 5 °C

3.2: 75 percent / Cu₂O / methanol; acetone

4.1: 86 percent / DBU / toluene / 2 h / 80 - 90 °C

5.1: 80 percent / DIBAL-H / toluene; CH₂Cl₂ / 2 h / 20 °C

6.1: 90 percent / MnO₂ / CH₂Cl₂ / 16 h / 20 °C

7.1: NaH / dimethylformamide / 0.5 h

8.1: 1.29 g / H₂ / 5 percent Pd/C / tetrahydrofuran; ethanol / 760 Torr

With manganese(IV) oxide; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1248/cpb.50.100

Reference yield:

: 178610-64-5
3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline

: 421558-49-8
5-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]valeronitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaNO₂; HBr / methanol; acetone / 0.25 h / 5 °C

1.2: 75 percent / Cu₂O / methanol; acetone

2.1: 86 percent / DBU / toluene / 2 h / 80 - 90 °C

3.1: 80 percent / DIBAL-H / toluene; CH₂Cl₂ / 2 h / 20 °C

4.1: 90 percent / MnO₂ / CH₂Cl₂ / 16 h / 20 °C

5.1: NaH / dimethylformamide / 0.5 h

6.1: 1.29 g / H₂ / 5 percent Pd/C / tetrahydrofuran; ethanol / 760 Torr

With manganese(IV) oxide; hydrogen bromide; hydrogen; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1248/cpb.50.100