t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate

Base Information

• Chemical Name: t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate
• CAS No.: 1245931-81-0
• Molecular Formula: C₂₈H₂₇FN₂O₅
• Molecular Weight: 490.531
• Mol file: 1245931-81-0.mol

Synonyms:t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate

Chemical Property of t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate

There total 1 articles about t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorobenzenamine (479690-04-5) + di-tert-butyl dicarbonate (24424-99-5) → t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate (1245931-81-0)

Guidance literature:

With NaH; In tetrahydrofuran;

Reference yield: 99.0%

t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate (1245931-81-0) → tert-butyl N-(3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)carbamate (1245931-82-1)

Guidance literature:

palladium-carbon; In ethanol;

Reference yield:

t-butyl 4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenylcarbamate (1245931-81-0) → 3-(4-(4-(tert-butoxycarbonyl)-2-fluorophenoxy)-6-methoxyquinolin-7-yloxy)propyl methanesulfonate

Guidance literature:

Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

2: potassium carbonate / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In ethanol; dichloromethane;

upstream raw materials:

4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorobenzenamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl N-(3-fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)carbamate

tert-butyl N-(3-fluoro-4-(7-(3-hydroxypropoxy)-6-methoxyquinolin-4-yloxy)phenyl)carbamate