Technology Process of (S)-3,4-dihydro-3-phenyl-5,6-benzocoumarin
There total 5 articles about (S)-3,4-dihydro-3-phenyl-5,6-benzocoumarin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(2-(1,3-dithian-2-ylidene)-2-phenylethyl)naphthalen-2-ol;
With
(R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate;
In
cyclohexane;
for 48h;
With
iodine; sodium hydrogencarbonate;
In
tetrahydrofuran; water-d2;
for 0.0666667h;
enantioselective reaction;
DOI:10.1021/ja3096202
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trimethylaluminum / dichloromethane; hexane / 0 - 20 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: (R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate / cyclohexane / 48 h
2.2: 0.07 h
With
(R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate; trimethylaluminum;
In
hexane; dichloromethane; cyclohexane;
DOI:10.1021/ja3096202
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen; 10% Pd/C / ethyl acetate / 20 °C / 750.08 Torr
2.1: trimethylaluminum / dichloromethane; hexane / 0 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: (R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate / cyclohexane / 48 h
3.2: 0.07 h
With
(R)-3,3'-bis[3,5-di(trifluoromethyl)phenyl]-1,1'-binaphthyl phosphate; 10% Pd/C; hydrogen; trimethylaluminum;
In
hexane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ja3096202
