Technology Process of ((2S,3R)-1-(benzyloxy)-3-methyl-4-((R)-oxiran-2-yl)butan-2-yloxy)-(tert-butyl)dimethylsilane
There total 7 articles about ((2S,3R)-1-(benzyloxy)-3-methyl-4-((R)-oxiran-2-yl)butan-2-yloxy)-(tert-butyl)dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C20H34O3Si;
With
sodium persulfate; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; coppertrifluoroacetate hydrate; lithium chloride;
In
water; acetonitrile;
at 10 ℃;
for 5h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
water; acetonitrile;
at 0 ℃;
for 0.25h;
Inert atmosphere;
With
potassium hydroxide;
In
ethanol; water; acetonitrile;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1039/c3ob41088a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Noyori's catalyst; potassium carbonate / isopropyl alcohol; dichloromethane / 24 h / 55 °C / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere
4.1: dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: lithium borohydride / tetrahydrofuran; methanol / 12 h / 0 - 20 °C / Inert atmosphere
6.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
7.1: (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; coppertrifluoroacetate hydrate; lithium chloride; sodium persulfate / acetonitrile; water / 5 h / 10 °C / Inert atmosphere
7.2: 0.25 h / 0 °C / Inert atmosphere
7.3: 1 h / 20 °C / Inert atmosphere
With
1H-imidazole; sodium persulfate; lithium borohydride; Noyori's catalyst; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; coppertrifluoroacetate hydrate; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
6.1: |Dess-Martin Oxidation;
DOI:10.1039/c3ob41088a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere
2.1: lithium borohydride / tetrahydrofuran; methanol / 12 h / 0 - 20 °C / Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4.1: (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; coppertrifluoroacetate hydrate; lithium chloride; sodium persulfate / acetonitrile; water / 5 h / 10 °C / Inert atmosphere
4.2: 0.25 h / 0 °C / Inert atmosphere
4.3: 1 h / 20 °C / Inert atmosphere
With
sodium persulfate; lithium borohydride; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; coppertrifluoroacetate hydrate; Dess-Martin periodane; lithium chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
3.1: |Dess-Martin Oxidation;
DOI:10.1039/c3ob41088a
