(1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester
• CAS No.: 213838-15-4
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.239
• Mol file: 213838-15-4.mol

Synonyms:(1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester

Chemical Property of (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester

There total 10 articles about (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1S,2R,6R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-6-methyl-cyclohex-3-enecarboxylic acid methyl ester (178991-19-0) → (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester (213838-15-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 3750.3 Torr;

DOI:10.1016/0957-4166(96)00190-5

Reference yield: 89.0%

(1S,2R,6R)-2-Benzyloxycarbonylamino-6-methylcyclohexane-1-carboxylic acid methyl ester (213838-14-3) → (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester (213838-15-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; formic acid; for 19h;

DOI:10.1021/jo980647q

Reference yield:

(1S,2R,3S)-3-Methyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester → (1S,2R,6R)-2-Amino-6-methyl-cyclohexanecarboxylic acid methyl ester (213838-15-4)

Guidance literature:

Multi-step reaction with 4 steps

1: PLE, phosphate buffer, NaOH / H₂O / 120 h / Ambient temperature

2: 96 percent / diethyl ether

4: 89 percent / H₂ / Pd/C / methanol; formic acid / 19 h

With sodium hydroxide; phosphate buffer; hydrogen; palladium on activated charcoal; In methanol; formic acid; diethyl ether; water;

DOI:10.1021/jo980647q

upstream raw materials:

(1S,2R,6R)-2-[Benzyl-((R)-1-phenyl-ethyl)-amino]-6-methyl-cyclohex-3-enecarboxylic acid methyl ester

(1S,2R,6R)-2-Benzyloxycarbonylamino-6-methylcyclohexane-1-carboxylic acid methyl ester

(1R,2S,3R)-3-Methyl-cyclohexane-1,2-dicarboxylic acid 1-methyl ester

(1R,2S,3R)-3-Methyl-cyclohexane-1,2-dicarboxylic acid dimethyl ester