tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

Base Information

Chemical Name:tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate
CAS No.:868665-54-7
Molecular Formula:C₂₄H₂₉ClN₄O₅S
Molecular Weight:521.037
Hs Code.:

Synonyms:tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

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Chemical Property of tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

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Technology Process of tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

There total 6 articles about tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868665-56-9
tert-butyl (1R)-1-benzyl-3-({2-chloro-6-[methyl(methylsulfonyl)amino]isonicotinoyl}amino)-1-methyl-2-oxopropylcarbamate

: 868665-54-7
tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

Guidance literature:: With methoxycarbonylsulfamoyl-triethylammonium hydroxide; In toluene; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 42521-09-5
methyl 2,6-dichloroisonicotinate

: 868665-54-7
tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 100 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: pH 3 - 4

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 3.5 h / 20 °C

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 16 h / 20 °C

5.1: methoxycarbonylsulfamoyl-triethylammonium hydroxide / toluene / 0.5 h / 130 °C / Microwave irradiation

With methanol; sodium hydroxide; potassium phosphate; 1-hydroxy-7-aza-benzotriazole; methoxycarbonylsulfamoyl-triethylammonium hydroxide; water; sulfur trioxide pyridine complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 853304-06-0
methyl 2-chloro-6-[methyl(methylsulfonyl)amino]isonicotinate

: 868665-54-7
tert-butyl (1R)-1-(2-{2-chloro-6-[methyl(methylsulfonyl)amino]pyridin-4-yl}-1,3-oxazol-5-yl)-1-methyl-2-phenylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C

1.2: pH 3 - 4

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 3.5 h / 20 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 16 h / 20 °C

4.1: methoxycarbonylsulfamoyl-triethylammonium hydroxide / toluene / 0.5 h / 130 °C / Microwave irradiation

With methanol; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; methoxycarbonylsulfamoyl-triethylammonium hydroxide; water; sulfur trioxide pyridine complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; dimethyl sulfoxide; toluene;