2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

Base Information

Chemical Name:2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine
CAS No.:217302-57-3
Molecular Formula:C₂₆H₂₃NO₂
Molecular Weight:381.474
Hs Code.:

Synonyms:2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

Chemical Property:

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Technology Process of 2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

There total 10 articles about 2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 217303-01-0
ethyl 7-benzyloxy-3-(4-benzyloxyphenyl)-4-ethylpyrrolo[2,1,5-cd]indolizine-2-carboxylate

: 217302-57-3
2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

Guidance literature:

Reference yield:

: 217302-56-2
3-(4-benzyloxyphenyl)-4-ethyl-5-hydroxymethylpyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid

: 217302-57-3
2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

Guidance literature:: With quinoline; copper; at 170 ℃;
DOI:10.1016/S0960-894X(00)00474-1

Reference yield:

: 4254-67-5
2-bromo-1-(4-benzyloxyphenyl)-1-ethanone

: 217302-57-3
2-(4-benzyloxyphenyl)-1-ethyl-7-hydroxymethylpyrrolo[2,1,5-cd]indolizine

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetone / Heating

1.2: aq. NaHCO₃ / Heating

3.1: toluene / 0 °C

3.2: DDQ / Heating

4.1: aq. KOH / methanol / Heating

5.1: Cu; quinoline / 170 °C

With quinoline; potassium hydroxide; copper; In methanol; acetone; toluene; 1.1: quaternization / 1.2: Cyclization / 2.1: silylation / 3.1: Cycloaddition / 3.2: Oxidation / 4.1: Hydrolysis / 5.1: Decarboxylation;
DOI:10.1016/S0960-894X(00)00474-1