{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Base Information

Chemical Name:{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester
CAS No.:114491-98-4
Molecular Formula:C₂₄H₃₆Cl₃F₃N₄O₃
Molecular Weight:591.929
Hs Code.:

Synonyms:{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

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Chemical Property of {4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

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Technology Process of {4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

There total 5 articles about {4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 114491-96-2
N¹-(tert-butoxycarbonyl)-N⁴-benzyl-N⁹-(2,2,2-trichloro-tert-butoxycarbonyl)-N¹²-(trifluoroacetyl)spermine

: 114491-98-4
{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: With trifluoroacetic acid; for 0.333333h; Ambient temperature;
DOI:10.1021/jo00248a037

Reference yield:

: 90914-14-0
N⁴-Benzyl-N¹-(tert-butoxycarbonyl)spermidine

: 114491-98-4
{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / methanol / 24 h / Ambient temperature

2: 75 percent / NaOH, hydrogen / W-2 Raney nickel / ethanol / 15 h / 2068.6 Torr

3: 82 percent / CH₂Cl₂; benzene / 2 h / 0 °C

4: 86 percent / 0.2 N aq. NaOH / diethyl ether / 0.17 h

5: 90 percent / trifluoroacetic acid / 0.33 h / Ambient temperature

With sodium hydroxide; hydrogen; trifluoroacetic acid; W-2 Raney nickel; In methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00248a037

Reference yield:

: 114491-93-9
1--4-benzyl-4,9-diazadodecanenitrile

: 114491-98-4
{4-[(3-Amino-propyl)-benzyl-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NaOH, hydrogen / W-2 Raney nickel / ethanol / 15 h / 2068.6 Torr

2: 82 percent / CH₂Cl₂; benzene / 2 h / 0 °C

3: 86 percent / 0.2 N aq. NaOH / diethyl ether / 0.17 h

4: 90 percent / trifluoroacetic acid / 0.33 h / Ambient temperature

With sodium hydroxide; hydrogen; trifluoroacetic acid; W-2 Raney nickel; In diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00248a037