ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

Base Information

Chemical Name:ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate
CAS No.:163164-06-5
Molecular Formula:C₂₉H₃₁NO₅
Molecular Weight:473.569
Hs Code.:

Synonyms:ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

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Chemical Property of ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

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Technology Process of ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

There total 8 articles about ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 54373-15-8
4-(2-chloroethoxy)benzaldehyde

: 163163-94-8
ethyl (E)-7-(4-hydroxyphenyl)-7-(3-pyridyl)hept-6-enoate

: 163164-06-5
ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

Guidance literature:: With sodium hydride; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 18h;
DOI:10.1021/jm00010a005

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 163164-06-5
ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) Et₂O, hexane, -70 deg C, 2.) Et₂O, hexane, THF, -70 deg C, 1 h

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 45 min, 2.) CH₂Cl₂, from -70 deg C to 25 deg C

3: 1.) dimsylsodium / 1.) DMSO, 20 min, 2.) DMSO, 4 h

4: 48percent aq. HBr / 4 h / Heating

5: SOCl₂ / 3 h / Ambient temperature

6: 18 percent / NaH, KI / dimethylformamide / 18 h / 60 °C

With n-butyllithium; thionyl chloride; oxalyl dichloride; dimsylsodium; hydrogen bromide; sodium hydride; dimethyl sulfoxide; triethylamine; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00010a005

Reference yield:

: 23826-71-3
3-(4-methoxybenzoyl)pyridine

: 163164-06-5
ethyl (E)-7-(3-pyridyl)-7-<4-<<2-<(4-formylphenyl)oxy>ethyl>oxy>phenyl>hept-6-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) dimsylsodium / 1.) DMSO, 20 min, 2.) DMSO, 4 h

2: 48percent aq. HBr / 4 h / Heating

3: SOCl₂ / 3 h / Ambient temperature

4: 18 percent / NaH, KI / dimethylformamide / 18 h / 60 °C

With thionyl chloride; dimsylsodium; hydrogen bromide; sodium hydride; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00010a005